Clinicopathologic correlations of renal pathology in the adult population of Poland
Ładowanie...
Data
2017
Inny tytuł
Typ
Artykuł recenzyjny
Redaktor
dc.contributor.advisor
Dyscyplina PBN
Psychologia
Czasopismo lub seria
Nephrology Dialysis Transplantation
ISSN
0931-0509
1460-2385
1460-2385
ISBN
DOI
10.1093/ndt/gfw365
Strona internetowa
Wydawca
Wydawca
Wydanie
Numer
Strony od-do
Tytuł monografii
item.page.defence
Tytuł tomu
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Abstrakt (en)
Background. This is the first report on the epidemiology of bi opsy-proven kidney diseases in Poland. Methods. The Polish Registry of Renal Biopsies has collected information on all (n = 9394) native renal biopsies performed in Poland from 2009 to 2014. Patients’ clinical data collected at the time of biopsy, and histopathological diagnoses were used for epidemiological and clinicopathologic analysis. Results. There was a gradual increase in the number of native renal biopsies performed per million people (PMP) per year in Poland in 2009–14, starting from 36 PMP in 2009 to 44 PMP in 2014. A considerable variability between provinces in the mean number of biopsies performed in the period covered was found, ranging from 5 to 77 PMP/year. The most common renal bi opsy diagnoses in adults were immunoglobulin A nephropathy (IgAN) (20%), focal segmental glomerulosclerosis (FSGS) (15%) and membranous glomerulonephritis (MGN) (11%), whereas in children, minimal change disease (22%), IgAN (20%) and FSGS (10%) were dominant. Due to insufficient data on the paediatric population, the clinicopathologic analysis was limited to patients ≥18 years of age. At the time of renal biopsy, the majority of adult patients presented nephrotic range proteinuria (45.2%), followed by urinary abnormalities (38.3%), nephritic syndrome (13.8%) and isolated haematuria (1.7%). Among nephrotic patients, primary glomerulopathies dominated (67.6% in those 18–64 years of age and 62.4% in eld erly patients) with leading diagnoses being MGN (17.1%), FSGS (16.2%) and IgAN (13.0%) in the younger cohort and MGN (23.5%), amyloidosis (18.8%) and FSGS (16.8%) in the elderly cohort. Among nephritic patients 18–64 years of age, the majority (55.9%) suffered from primary glomerulopathies, with a predominance of IgAN (31.3%), FSGS (12.7%) and cres centic GN (CGN) (11.1%). Among elderly nephritic patients, primary and secondary glomerulopathies were equally com mon (41.9% each) and pauci-immune GN (24.7%), CGN (20.4%) and IgAN (14.0%) were predominant. In both adult co horts, urinary abnormalities were mostly related to primary glo merulopathies (66.8% in younger and 50% in elderly patients) and the leading diagnoses were IgAN (31.4%), FSGS (15.9%), lupus nephritis (10.7%) and FSGS (19.2%), MGN (15.1%) and pauci-immune GN (12.3%), respectively. There were sig nificant differences in clinical characteristics and renal biopsy findings between male and female adult patients. Conclusions. The registry data focused new light on the epi demiology of kidney diseases in Poland. These data should be used in future follow-up and prospective studies.