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Captopril apparently increase and cisplatin apparently decrease human albumin concentration in artificial urinary solutions

cris.lastimport.scopus2024-09-18T01:31:16Z
dc.abstract.enBackground: Measurement of urinary albumin (HSA) is very important in diagnostic of kidney diseases. Much less is known about the possible impact of substances present in urine together with albumin on the results of measurements.Methods: We investigated the effect of the presence of captopril and cisplatin in the solution on the result of the determination of HSA by native polyacrylamide gel elec-trophoresis. Protein conformation in the absence and presence of the drugs was ex-amined using Fourier Transform Infrared Spectroscopy (FTIR).Results: The presence of captopril apparently increases HSA concentration while cispl-atin causes an apparent decrease in the HSA concentration. The presence of both drugsalso influence the secondary structure forms of HSA albumin investigated by FTIR.Conclusion: Both drugs tested in the concentration of human use can have an impact on the results of determination of albumin in urine which can influence clinical decision.
dc.affiliationNauk o Człowieku
dc.contributor.authorRafał Kuzioła
dc.contributor.authorBarbara Marczewska
dc.contributor.authorKrzysztof Marczewski
dc.date.accessioned2024-04-30T07:16:28Z
dc.date.available2024-04-30T07:16:28Z
dc.date.issued2017
dc.identifier.doi10.1002/jcla.22127
dc.identifier.issn0887-8013
dc.identifier.issn1098-2825
dc.identifier.urihttps://repo.akademiawsei.eu/handle/item/264
dc.languageen
dc.pbn.affiliationpsychology
dc.relation.ispartofJournal of Clinical Laboratory Analysis
dc.rightsCC-BY-NC
dc.subject.endrugs interference
dc.subject.ennative polyacrylamide gel electrophoresis
dc.subject.enurine albumin determination
dc.titleCaptopril apparently increase and cisplatin apparently decrease human albumin concentration in artificial urinary solutions
dc.typeReviewArticle
dspace.entity.typePublication
oaire.citation.issue6
oaire.citation.volume31