Captopril apparently increase and cisplatin apparently decrease human albumin concentration in artificial urinary solutions
Ładowanie...
Data
2017
Inny tytuł
Typ
Artykuł recenzyjny
Redaktor
dc.contributor.advisor
Dyscyplina PBN
Psychologia
Czasopismo lub seria
Journal of Clinical Laboratory Analysis
ISSN
0887-8013
1098-2825
1098-2825
ISBN
DOI
10.1002/jcla.22127
Strona internetowa
Wydawca
Wydawca
Wydanie
Numer
Strony od-do
Tytuł monografii
item.page.defence
Tytuł tomu
Opis
Rodzaj licencji
Abstrakt (en)
Background: Measurement of urinary albumin (HSA) is very important in diagnostic of kidney diseases. Much less is known about the possible impact of substances present in urine together with albumin on the results of measurements.Methods: We investigated the effect of the presence of captopril and cisplatin in the solution on the result of the determination of HSA by native polyacrylamide gel elec-trophoresis. Protein conformation in the absence and presence of the drugs was ex-amined using Fourier Transform Infrared Spectroscopy (FTIR).Results: The presence of captopril apparently increases HSA concentration while cispl-atin causes an apparent decrease in the HSA concentration. The presence of both drugsalso influence the secondary structure forms of HSA albumin investigated by FTIR.Conclusion: Both drugs tested in the concentration of human use can have an impact on the results of determination of albumin in urine which can influence clinical decision.